Research

Dedicated to advancing the understanding of bacterial interactions with the host, immune evasion and antibiotic resistance. Our interdisciplinary team combines molecular microbiology, immunology and genetic analysis to tackle some of the most pressing global health challenges.

Research profile

Neutrophils play a key role in host defense and have an ever-expanding list of roles in health and disease. However, neutrophil dysregulation can lead to catastrophic inflammation. In the intensive care unit, neutrophil dysfunction contributes to pathology in many diseases including sepsis, organ transplant, acute lung injury and stroke.

Research profile

Research in our lab is focused on traumatic brain injury (TBI). Specifically, we are focused on utilizing clinical relevant animal models of TBI to study the effects of secondary insults — intracranial hypertension, hypoxemia and neuroinflammation — after moderate and severe TBI.

Research profile

The Katira lab’s research focuses on novel mechanisms of lung injury associated with mechanical ventilation and critical care as well as developing strategies for personalized respiratory support and lung protection during critical illness. We have an expertise in using large animal models for developing translational research in critical illness as well as the application and development of advanced cardio-respiratory research tools such electrical impedance tomography.

Research profile

Our lab specializes in translational biomedical informatics, leveraging high-resolution electronic health record (EHR) data to develop machine learning-based, clinically applicable decision support tools.

Research profile

Our lab investigates the host response to pathogenic infections, specifically the mechanisms underlying antiviral innate immune responses. We are also focused on the role of the microbiota in the establishment and maintenance of antiviral immunity.

Research profile