Our labs
Clemens Lab
Regina Clemens, MD, PhD
Neutrophils play a key role in host defense and have an ever-expanding list of roles in health and disease. However, neutrophil dysregulation can lead to catastrophic inflammation. In the intensive care unit, neutrophil dysfunction contributes to pathology in many diseases including sepsis, organ transplant, acute lung injury and stroke.
Friess Lab
Stuart Friess, MD
Research in our lab is focused on traumatic brain injury (TBI). Specifically, we are focused on utilizing clinical relevant animal models of TBI to study the effects of secondary insults — intracranial hypertension, hypoxemia and neuroinflammation — after moderate and severe TBI.
Recent publications
- Gut microbial regulation of innate and adaptive immunity after traumatic brain injuryCelorrio, M., Shumilov, K. & Friess, S. H., Feb 2024, In: Neural Regeneration Research. 19, 2, p. 272-276 5 p.Research output: Contribution to journal › Review article › peer-review
- Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysisFan, Z., Kernan, K. F., Qin, Y., Canna, S., Berg, R. A., Wessel, D., Pollack, M. M., Meert, K., Hall, M., Newth, C., Lin, J. C., Doctor, A., Shanley, T., Cornell, T., Harrison, R. E., Zuppa, A. F., Sward, K., Dean, J. M., Park, H. J. & Carcillo, J. A., Dec 2023, In: Critical Care. 27, 1, 347.Research output: Contribution to journal › Article › peer-review
- The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomesthe ICU-RESUS and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups, Friess, S. H. & Manga, A., Dec 2023, In: Critical Care. 27, 1, 105.Research output: Contribution to journal › Article › peer-review
- Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation studyGardner, M. M., Hehir, D. A., Reeder, R. W., Ahmed, T., Bell, M. J., Berg, R. A., Bishop, R., Bochkoris, M., Burns, C., Carcillo, J. A., Carpenter, T. C., Dean, J. M., Diddle, J. W., Federman, M., Fernandez, R., Fink, E. L., Franzon, D., Frazier, A. H., Friess, S. H., Graham, K., & 26 othersHall, M., Harding, M. L., Horvat, C. M., Huard, L. L., Maa, T., Manga, A., McQuillen, P. S., Meert, K. L., Morgan, R. W., Mourani, P. M., Nadkarni, V. M., Naim, M. […]
- Prevalence and Characteristics of Diagnostic Error in Pediatric Critical Care: A Multicenter Study∗Cifra, C. L., Custer, J. W., Smith, C. M., Smith, K. A., Bagdure, D. N., Bloxham, J., Goldhar, E., Gorga, S. M., Hoppe, E. M., Miller, C. D., Pizzo, M., Ramesh, S., Riffe, J., Robb, K., Simone, S. L., Stoll, H. D., Tumulty, J. A., Wall, S. E., Wolfe, K. K., Wendt, L., & 6 othersTen Eyck, P., Landrigan, C. P., Dawson, J. D., Reisinger, H. S., Singh, H. & Herwaldt, L. A., Nov 1 2023, In: Critical care medicine. 51, 11, p. 1492-1501 10 p.Research output: Contribution […]
- Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective studyPOKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric & Neonatal Intensive Care), and & the Novel Data-Driven Sepsis Phenotypes in Children study group, Nov 2023, In: EClinicalMedicine. 65, 102252.Research output: Contribution to journal › Article › peer-review
- Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidaseSong, Z., Bhattacharya, S., Clemens, R. A. & Dinauer, M., Oct 20 2023, In: iScience. 26, 10, 108034.Research output: Contribution to journal › Review article › peer-review
- Acute Disorders of Consciousness in Pediatric Severe Sepsis and Organ Failure: Secondary Analysis of the Multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study*Cheung, C., Kernan, K. F., Berg, R. A., Zuppa, A. F., Notterman, D. A., Pollack, M. M., Wessel, D., Meert, K. L., Hall, M. W., Newth, C., Lin, J. C., Doctor, A., Shanley, T., Cornell, T., Harrison, R. E., Banks, R. K., Reeder, R. W., Holubkov, R., Carcillo, J. A. & Fink, E. L., Oct 1 2023, In: Pediatric Critical Care Medicine. 24, 10, p. 840-848 9 p.Research output: Contribution to journal › Article › peer-review
- Association of CPR simulation program characteristics with simulated and actual performance during paediatric in-hospital cardiac arrestthe Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatrics Critical Care Research Network (CPCCRN) & National Heart Lung and Blood Institute ICU-RESUScitation Project Investigators, Oct 2023, In: Resuscitation. 191, 109939.Research output: Contribution to journal › Article › peer-review
- Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*Sanchez-Pinto, L. N., Bennett, T. D., Stroup, E. K., Luo, Y., Atreya, M., Bubeck Wardenburg, J., Chong, G., Geva, A., Faustino, E. V. S., Farris, R. W., Hall, M. W., Rogerson, C., Shah, S. S., Weiss, S. L. & Khemani, R. G., Oct 1 2023, In: Pediatric Critical Care Medicine. 24, 10, p. 795-806 12 p.Research output: Contribution to journal › Article › peer-review